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Proglumide sodium salt is a non-selective, orally active cholecystokinin (CCK) antagonist. Proglumide sodium inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Proglumide sodium blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment.
| Molecular Weight | 356.39 |
| Formula | C18H25N2NaO4 |
| CAS Number | 99247-33-3 |
| Solubility (25°C) | Water 35.64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cholecystokinin Receptor Products |
|---|
| Pentagastrin
Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally. |
| Lintitript
Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). |
| Lorglumide sodium salt
Lorglumide (CR-1409) sodium salt is a potent cholecystokinin (CCK) receptor antagonist. |
| Ceruletide
Ceruletide is a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, acts as a cholecystokinin receptor agonist. |
| Gastrin-I (human)
Gastrin-I (human) is the endogenous peptide produced in the stomach, which increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
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