All AbMole products are for research use only, cannot be used for human consumption.
Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. Procyanidin B2 shows antiproliferative activity to MCF-7 cells, with an IC50 of 19.21 μM. Procyanidin B2 (0.1, 1, 2 μM) inhibits the activation of pyrin domain containing 3 (NLRP3) inflammasome in HUVECs.
Procyanidin B2 (40, 20, and 10 mg/kg, p.o.) protects against cerebral ischemia-induced infarct volume and brain edema in rats.
| Molecular Weight | 578.52 |
| Formula | C30H26O12 |
| CAS Number | 29106-49-8 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL Water 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NLR Products |
|---|
| Nodinitib-1
Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| Ruscogenin
Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| Oridonin
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| Shionone
Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
| (E)-Cardamonin
(E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
