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PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.
| Molecular Weight | 185.22 |
| Formula | C9H15NO3 |
| CAS Number | 5608-24-2 |
| Solubility (25°C) | DMSO: ≥ 36 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related p53 Products |
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| Tenovin-1
Tenovin-1 is a small molecule activator of p53 transcriptional activity. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor. |
| Pifithrin-α
Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| JNJ-26854165
JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines. |
| Inauhzin
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| Tenovin-6
Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
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