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Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury.
| Molecular Weight | 341.49 |
| Formula | C22H31NO2 |
| CAS Number | 1434-54-4 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Pregnane X Receptor Products |
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| SR 12813
SR 12813 is an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR). SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM. |
| Citral
Citral is a monoterpene found in Cymbopogon citratus essential oil, with antihyperalgesic, anti-nociceptive and anti-inflammatory effects. Citral has been shown to activate PXR and induce its target genes. Citral is also a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines. |
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