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Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. It can be used to construct autoimmune hepatitis models.
| Molecular Weight | 360.44 |
| Formula | C21H28O5 |
| CAS Number | 50-24-8 |
| Solubility (25°C) | DMSO 62 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] S Melhorn, et al. Formulations for emergencies-prednisolone oral liquid
[3] A A LEWIS. Methyl-prednisolone
[4] S S Hayreh, et al. Prednisolone-21-stearoylglycolate in scleritis
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