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Pravastatin

Cat. No. M20528

All AbMole products are for research use only, cannot be used for human consumption.

Pravastatin Structure

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Quality Control & Documentation
Biological Activity

Pravastatin is an HMG-CoA reductase (HMGCR) inhibitor that inhibits sterol synthesis with an IC50 of 5.6 μM.

Chemical Information
Molecular Weight 424.53
Formula C23H36O7
CAS Number 81093-37-0
Solubility (25°C) DMSO 85 mg/mL
Water 85 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zahid Ijaz Tarar, et al. J Investig Med High Impact Case Rep. Pravastatin-Induced Acute Pancreatitis: A Case Report and Literature Review

[2] Wanda Gajzlerska-Majewska, et al. J Perinat Med. Is pravastatin a milestone in the prevention and treatment of preeclampsia?

[3] Enrique Esteve-Valverde, et al. Obstet Gynecol Surv. Pravastatin for Preventing and Treating Preeclampsia: A Systematic Review

[4] Abdullah A Al-Badr, et al. Profiles Drug Subst Excip Relat Methodol. Pravastatin sodium

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Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

Rosuvastatin calcium

Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.

Mevastatin

Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.

Pravastatin sodium

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

Clinofibrate

Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.

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Keywords: Pravastatin supplier, HMG-CoA Reductase, inhibitors, activators

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