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Pralnacasan

Cat. No. M10905

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Pralnacasan Structure
Synonym:

VX-740; HMR 3480

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Quality Control & Documentation
Biological Activity

Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis.

Chemical Information
Molecular Weight 523.54
Formula C₂₆H₂₉N₅O₇
CAS Number 192755-52-5
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christian Bauer, et al. Gut. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

[2] Christian Bauer, et al. Dig Dis Sci. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression

[3] Florian Loher, et al. J Pharmacol Exp Ther. The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation

[4] K Rudolphi, et al. Osteoarthritis Cartilage. Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

[5] Britta Siegmund, et al. IDrugs. Pralnacasan (vertex pharmaceuticals)

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Keywords: Pralnacasan, VX-740; HMR 3480 supplier, Caspase, inhibitors, activators

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