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PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.
| Molecular Weight | 372.42 |
| Formula | C22H20N4O2 |
| CAS Number | 875634-01-8 |
| Solubility (25°C) | DMSO 37.24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Wong, et al. Science. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
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