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PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM. PPTN hydrochloride has anti-inflammatory and anti-immune activity.
| Molecular Weight | 511.96 |
| Formula | C29H25ClF3NO2 |
| CAS Number | 1992047-65-0 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage | 4°C, dry, sealed |
| Related P2 Receptor Products |
|---|
| Prasugrel hydrochloride
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| GW 791343 dihydrochloride
GW 791343 dihydrochloride is a non-competitive inhibitor of human P2X(7) receptor. |
| Prasugrel
Prasugrel is a platelet inhibitor irreversibly binding to P2Y12 receptors. |
| MRS 2578
MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| PPADS Tetrasodium
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist blocking recombinant P2X1, P2X2, P2X3, P2X5 with IC50 of 1-2.6 μM, native P2Y2-like with IC50 of ~ 0.9 mM, and recombinant P2Y4 receptors with IC50 of ~ 15 mM |
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Products are for research use only. Not for human use. We do not sell to patients.
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