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PPADS is a non-selective P2X receptor antagonist. PPADS blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.
| Molecular Weight | 511.38 |
| Formula | C14H14N3O12PS2 |
| CAS Number | 149017-66-3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Marie E Gibbs, et al. ATP derived from astrocytes modulates memory in the chick
[4] Brian D Gulbransen, et al. Purinergic neuron-to-glia signaling in the enteric nervous system
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| PPADS Tetrasodium
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist blocking recombinant P2X1, P2X2, P2X3, P2X5 with IC50 of 1-2.6 μM, native P2Y2-like with IC50 of ~ 0.9 mM, and recombinant P2Y4 receptors with IC50 of ~ 15 mM |
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