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PPADS Tetrasodium

Cat. No. M2954

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PPADS Tetrasodium Structure
Size Price Availability Quantity
5mg USD 320 In stock
10mg USD 600 In stock
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Quality Control & Documentation
Biological Activity

PPADS tetrasodium salt is a non-selective P2 purinergic antagonist blocking recombinant P2X1, P2X2, P2X3, P2X5 with IC50 of 1-2.6 μM, native P2Y2-like with IC50 of ~ 0.9 mM, and recombinant P2Y4 receptors with IC50 of ~ 15 mM.

Chemical Information
Molecular Weight 599.3
Formula C14H10N3Na4O12PS2
CAS Number 192575-19-2
Solubility (25°C) Water 40 mg/mL
Storage -20°C, dry, sealed
References

[1] Hong Huo, et al. J Biol Chem. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region

[2] Edgar Flores-Soto, et al. Eur J Pharmacol. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle

[3] Sylvia Rost, et al. Kidney Int. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis

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Keywords: PPADS Tetrasodium supplier, P2 Receptor, inhibitors, activators

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