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Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction. Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.
When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.
| Solubility (25°C) | Soluble in water Soluble in aqueous buffer |
| Storage | -20°C, sealed |
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