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Pomalidomide-piperazine 

Cat. No. M57112

All AbMole products are for research use only, cannot be used for human consumption.

Pomalidomide-piperazine  Structure

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Quality Control & Documentation
Biological Activity

Pomalidomide-piperazine is an active compound that can be used to synthesis the E3 ligand for PROTAC.

Chemical Information
Molecular Weight 342.35
Formula C17H18N4O4
CAS Number 2154342-57-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related Ligand for E3 Ligase Products
Pomalidomide

Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.

Thalidomide

Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.

VH-298

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.

VHL Ligand 1 hydrochloride

VHL Ligand 1 hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

E3 ligase Ligand 1

E3 ligase Ligand 1 (VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

  Catalog
Abmole Inhibitor Catalog




Keywords: Pomalidomide-piperazine  supplier, Ligand for E3 Ligase, inhibitors, activators

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