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Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA, is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the number and tumoricidal activities of various immunohematopoietic cells. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses.
Gene. 2024 Mar 1;897:148049.
Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice
Polyinosinic:polycytidylic acid purchased from AbMole
| Molecular Weight | 671.40 |
| Formula | C19H27N7O16P2 |
| CAS Number | 24939-03-5 |
| Solubility (25°C) | Water 30 mg/mL |
| Storage |
Powder -20°C, dry, sealed In solvent -20°C 1 month |
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