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Polygalasaponin-F

Cat. No. M4539

All AbMole products are for research use only, cannot be used for human consumption.

Polygalasaponin-F Structure
Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 120 In stock
20mg USD 180 In stock
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Quality Control & Documentation
Biological Activity

Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway.

Chemical Information
Molecular Weight 1091.24
Formula C53H86O23
CAS Number 882664-74-6
Solubility (25°C) DMSO 100 mg/mL
Storage 4°C, protect from light
References

[1] Chong Sun, et al. Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity

[2] Wei Xie, et al. Polygalasaponin F inhibits neuronal apoptosis induced by oxygen-glucose deprivation and reoxygenation through the PI3K/Akt pathway

[3] Yi Ye, et al. Polygalasaponin F treats mice with pneumonia induced by influenza virus

[4] Wei Wei, et al. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation

[5] Feng Sun, et al. Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation

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Keywords: Polygalasaponin-F supplier, TLR, inhibitors, activators

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