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Poloxin is a non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor that targets the polo-box domain. Poloxin inductees Plk1 mislocalization, chromosome congression defects, mitotic arrest, and apoptosis in HeLa cells.
| Molecular Weight | 297.35 |
| Formula | C18H19NO3 |
| CAS Number | 321688-88-4 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Iryna Kolosenko, et al. Small-molecule inhibitors for targeting polo-like kinase 1
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