All AbMole products are for research use only, cannot be used for human consumption.
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. PLX5622 eliminates microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition.
In vivo, PLX5622 (65 mg/kg/day; oral gavage for 14 days) causes paw withdrawal threshold high in mice, indicating that PLX5622 prevents the development of injury-associated mechanical allodynia.
J Nanobiotechnology. 2025 Nov 30;23:740.
Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia.
PLX5622 purchased from AbMole
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| Molecular Weight | 395.41 |
| Formula | C21H19F2N5O |
| CAS Number | 1303420-67-8 |
| Solubility (25°C) | DMSO ≥ 65 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CSF-1R (c-Fms) Products |
|---|
| GW2580
GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| PLX647
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. |
| BLZ945 (Sotuletinib)
Sotuletinib (BLZ945) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. |
| Ki 20227
Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation. |
| cFMS Receptor Inhibitor II
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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