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Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
| Molecular Weight | 1681.89 |
| Formula | C65H104N18O26S4 |
| CAS Number | 467426-54-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] No authors listed. Plecanatide
[3] No authors listed. Plecanatide
[4] Zaina T Al-Salama, et al. Drugs. Plecanatide: First Global Approval
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