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Plazomicin Sulfate is a derivative of Sisomicin and a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis in a concentration-dependent manner, with broad-spectrum antimicrobial activity against aerobic Gram-negative bacteria, and can be used in studies related to pyelonephritis.
| Cell Experiment | |
|---|---|
| Cell lines | Escherichia coli |
| Preparation method | Bacteria were cultured in Lennox L broth (1% tryptone, 0.5% yeast extract, 0.5% NaCl) with the addition of 2% agar in the case of solid medium. Plazomicin resistance levels were determined in cation-adjusted Mueller-Hinton broth. Culturing was carried out at 37 °C in a shaker. |
| Concentrations | 0, 4, 8 μg/mL |
| Incubation time | Over night |
| Animal Experiment | |
|---|---|
| Animal models | Female ICR mice |
| Formulation | Sterile 0.9% sodium chloride solution |
| Dosages | 28 mg/kg |
| Administration | s.c. |
| Molecular Weight | 690.76 |
| Formula | C25H50N6O14S |
| CAS Number | 1380078-95-4 |
| Form | Solid |
| Storage | -20°C |
| Related Antibiotic Products |
|---|
| Kanamycin sulfate
Kanamycin sulfate is an aminoglycoside antibiotic that acts as a bacteriostatic agent by binding to the bacterial 30S ribosome. |
| Marbofloxacin
Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group which inhibiting bacterial DNA replication. |
| Linezolid
Linezolid (PNU-100766) is a synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. |
| Daptomycin
Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. |
| Sulfadimethoxine
Sulfadimethoxine (trade name Di-Methox, Albon) is a sulfonamide antibiotic. |
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