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Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity. Toxoflavin (Xanthothricin) disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. Toxoflavin (PKF118-310) inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
| Molecular Weight | 193.16 |
| Formula | C7H7N5O2 |
| CAS Number | 84-82-2 |
| Solubility (25°C) | Water 10 mg/mL DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Gianluigi Franci, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor
[5] Masuko Katoh, et al. WNT signaling pathway and stem cell signaling network
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