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Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1.
| Molecular Weight | 461.55 |
| Formula | C28H29F2N3O |
| CAS Number | 2062-78-4 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jussara Maria Gonalves, et al. Inhibition of cancer stem cells promoted by Pimozide
[2] Robert Smyj, et al. Pimozide
[3] Tamara Pringsheim, et al. Pimozide for tics in Tourette's syndrome
[4] J Rathbone, et al. Pimozide for schizophrenia or related psychoses
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