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PIM447

Cat. No. M27950

All AbMole products are for research use only, cannot be used for human consumption.

PIM447 Structure
Synonym:

LGH447

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Quality Control & Documentation
Biological Activity

PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis.

Chemical Information
Molecular Weight 440.46
Formula C24H23F3N4O
CAS Number 1210608-43-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jian Wu, et al. Cancers (Basel). PIM Kinases in Multiple Myeloma

[2] Nikita Wadhwani, et al. J Pediatr Surg. PIM447 inhibits oncogenesis and potentiates cisplatin effects in hepatoblastoma

[3] Teresa Paíno, et al. Cancers (Basel). Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma

[4] Teresa Paíno, et al. Clin Cancer Res. The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care

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Keywords: PIM447, LGH447 supplier, Pim, inhibitors, activators

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