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Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines.
| Molecular Weight | 611.51 |
| Formula | C26H29F3N5O7P |
| CAS Number | 2088852-47-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
[2] No authors listed. Cold Spring Harb Protoc. Phosphate-Limited Chemostat Medium
[3] Marc G Vervloet, et al. Nat Rev Nephrol. The role of phosphate in kidney disease
[4] Eleanor Lederer. J Physiol. Regulation of serum phosphate
[5] O Susan Iheagwara, et al. Hemodial Int. Phosphorus, phosphorous, and phosphate
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| SMI-4a
SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. |
| CX-6258
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. |
| TCS PIM-1 1
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| Hispidulin
Hispidulin is a natural flavonoid with a wide range of biological activities. Hispidulin is an inhibitor of PIM-1 with IC50 value of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. |
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