All AbMole products are for research use only, cannot be used for human consumption.
PIK-90 is a novel and potent PI3K inhibitor with IC50 values of 11 nM, 350 nM, 18 nM and 58 nM for p110α, p110β, p110γ and p110δ respectively. Phosphoinositide 3-kinases (PI3Ks) are among the most frequently activated signaling pathways in cancer. Inhibition with p110alpha inhibitor PIK-90 resulted in a significant reduction of chemotaxis and actin polymerization to CXCL12 and reduced migration beneath MSC (pseudoemperipolesis). In suspension and MSC cocultures, PIK-90 was potent inducers of CLL cell apoptosis.
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Source | Proc Natl Acad Sci U S A (2012). Figure 1.PIK-90 |
| Method | apoptosis assay | |
| Cell Lines | PTENWT and PTENMT glioma cell lines | |
| Concentrations | 0.5 μM | |
| Incubation Time | 24 h | |
| Results | Like PIK-90, PI-103, and LY294002, PIK-75 could block phosphorylation of Akt |
| Cell Experiment | |
|---|---|
| Cell lines | LN229:EGFR (PTENwt) and U87:EGFR (PTENmt) cells |
| Preparation method | Cell proliferation assay and flow cytometry. For viability, 10^5 cells were seeded in 12-well plates in the presence of erlotinib, PI-103, PIK-90, rapamycin, erlotinib plus PIK-90, erlotinib plus rapamycin, erlotinib plus PIK-90, and rapamycin or erlotinib plus PI-103 for 72 h. Cell viability was determined using a WST-1 assay (AbMole). |
| Concentrations | 0, 0.1, 0.5, 1µM |
| Incubation time | 72h |
| Animal Experiment | |
|---|---|
| Animal models | Human primary GBM43 cells female BALB/c nu/nu mice bearing xenografts model |
| Formulation | DMSO:H20 |
| Dosages | 40 mg/kg |
| Administration | daily i.p. |
| Molecular Weight | 351.36 |
| Formula | C18H17N5O3 |
| CAS Number | 677338-12-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PI3K Products |
|---|
| AS605240
AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) with an IC50 of 8 nM. |
| BEZ235
BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively. |
| BKM120 (Buparlisib)
BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor. |
| GDC-0941 (Pictilisib)
GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM. |
| AS-252424
AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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