All AbMole products are for research use only, cannot be used for human consumption.
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.
| Cell Experiment | |
|---|---|
| Cell lines | HT-29 colon cancer and HT1080 fibrosarcoma cells |
| Preparation method | Twenty-four hours after seeding, cells were treated with piericidin A in the presence or absence of glucose and 20 mM of 2DG and the plates were incubated for 18 h. |
| Concentrations | 0-100 nM |
| Incubation time | 18 h |
| Animal Experiment | |
|---|---|
| Animal models | Transgenic mice expressing human tau with the P301S-mutation (P301S+/+) |
| Formulation | 50% DMSO and 50% PEG |
| Dosages | 0.5 mg/kg/d |
| Administration | Injected subcutaneously |
| Molecular Weight | 415.57 |
| Formula | C25H37NO4 |
| CAS Number | 2738-64-9 |
| Form | Liquid |
| Storage | -20°C |
[5] M Matsumoto, et al. J Antibiot (Tokyo). New piericidin glucosides, glucopiericidins A and B
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