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PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to destabilization of the transcription factor Nanog, which is required for maintenance of embryonic stem cell cultures.
| Molecular Weight | 438.39 |
| Formula | C22H18N2O8 |
| CAS Number | 64005-90-9 |
| Solubility (25°C) | DMSO: 1-2 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Tanja Kero, et al. Quantification of 11 C-PIB kinetics in cardiac amyloidosis
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