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Physostigmine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor.
 |
Source | Behav Brain Res (2015). Figure 2. Physostigmine Salicylate |
| Method | i.p. | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 0.06 or 0.125 mg/kg | |
| Incubation Time | 24 h | |
| Results | Post-hoc analysis showed that 2 μg/side dose of physostigmine produced a significant increase in time spent immobile compared to saline |
 |
Source | Behav Brain Res (2015). Figure 1. Physostigmine Salicylate |
| Method | i.p. | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 0.06 or 0.125 mg/kg | |
| Incubation Time | 24 h | |
| Results | Subsequent examination and analysis of locomotor behavior showed that systemic administration of physostigmine did not alter locomotor activity compared to saline controls |
| Cell Experiment | |
|---|---|
| Cell lines | Human erythrocyte |
| Preparation method | Starting at maximum enzyme activity (t=30), erythrocyte AChE was inhibited with a short pulse (4 min) of physostigmine (250 nM) followed by a continuous perfusion of physostigmine (50 nM) for 30 min. |
| Concentrations | 50 nM |
| Incubation time | 30 min |
| Animal Experiment | |
|---|---|
| Animal models | Sprague–Dawley rats |
| Formulation | |
| Dosages | 0.1–0.4mg/kg |
| Administration | i.v. |
| Molecular Weight | 413.47 |
| Formula | C15H21N3O2.C7H6O3 |
| CAS Number | 57-64-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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