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PhiKan 083

Cat. No. M7135

All AbMole products are for research use only, cannot be used for human consumption.

PhiKan 083 Structure
Synonym:

PhiKan-083; PK083

Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 198 In stock
25mg USD 430 In stock
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Quality Control & Documentation
Biological Activity

PhiKan 083 is a carbazole derivative that stabilizes Y220C, a mutant of p53, with a Kd value of 167 μM.PhiKan 083 can be used in cancer-related research.

Chemical Information
Molecular Weight 238.00
Formula C16H18N2
CAS Number 880813-36-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Ethanol 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ramasamy Paulmurugan, et al. Oncotarget. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells

[2] Cheng, et al. J Pharmacol Exp Ther. Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.

[3] Shah Md Abdur Rauf, et al. Protein J. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach

[4] Frank M Boeckler, et al. Proc Natl Acad Sci U S A. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

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Keywords: PhiKan 083, PhiKan-083; PK083 supplier, p53, inhibitors, activators

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