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Phenytoin Sodium is a potent Voltage-gated Na+ channels (VGSCs) blocker. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
| Molecular Weight | 274.25 |
| Formula | C15H11N2NaO2 |
| CAS Number | 630-93-3 |
| Solubility (25°C) | DMSO 42 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Erenberk U, et al. Drug Chem Toxicol. Melatonin attenuates phenytoin sodium-induced DNA damage.
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