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Phenoxodiol is a synthetic genestein analogue that activates the mitochondrial caspase system and inhibits XIAP, an inhibitor of apoptosis, making cancer cells sensitive to FAS - mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing cleavable complexes, thereby preventing DNA replication.
| Molecular Weight | 240.25 |
| Formula | C15H12O3 |
| CAS Number | 81267-65-4 |
| Form | Solid |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Madeline Fink, et al. Triggering of eryptosis, the suicidal erythrocyte death, by phenoxodiol
[3] Ayesha B Alvero, et al. Anti-tumor activity of phenoxodiol: from bench to clinic
[4] Toni K Choueiri, et al. Phenoxodiol: isoflavone analog with antineoplastic activity
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