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Phenindione (Rectadione) is an anticoagulant which functions as a Vitamin K antagonist. A lymphocyte transformation test showed proliferation of T-cells from the hypersensitive patient, but not from four controls on exposure to phenindione in vitro. Drug-specific T-cell clones were generated and characterized in terms of their phenotype, functionality, and mechanism of antigen presentation. Forty-three human leukocyte antigen class II restricted CD4+ αβ T-cell clones were identified. T-cell activation resulted in the secretion of interferon-γ and interleukin-5.
| Molecular Weight | 222.24 |
| Formula | C15H10O2 |
| CAS Number | 83-12-5 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] A Sankaralingam, et al. Phenindione interferes with measurement of creatinine
[2] P W COPEMAN. PHENINDIONE TOXICITY
[3] J B ROSS. Side-effect of phenindione
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