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PF-06873600 is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. PF-06873600 has Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation.
| Molecular Weight | 471.52 |
| Formula | C20H27F2N5O4S |
| CAS Number | 2185857-97-8 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Kevin Freeman-Cook, et al. Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
[2] Rinath Jeselsohn, et al. Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2
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