PF-06835919

Cat. No. M21287

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

Ketohexokinase inhibitor 1

Size	Price	Availability	Quantity
5mg	USD 470	In stock
10mg	USD 660	In stock

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Quality Control & Documentation

Purity: >99%
COA
MSDS

Product Information

Biological Activity

PF-06835919 is an oral Class I clinical candidate for NAFLD/NASH, targeting ketohexokinase (KHK), an enzyme that initiates fructose metabolism.

Chemical Information

Molecular Weight	356.35
Formula	C16H19F3N4O2
CAS Number	2102501-84-6
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Yan Weng, et al. Drug Metab Dispos. Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease

[2] David A Tess, et al. Clin Pharmacol Ther. Effect of a Ketohexokinase Inhibitor (PF-06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug

[3] Jemy A Gutierrez, et al. Mol Metab. Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

[4] Kentaro Futatsugi, et al. J Med Chem. Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

[5] Suzanna L Attia, et al. Clin Transl Sci. Evolving Role for Pharmacotherapy in NAFLD/NASH

Catalog

Keywords: PF-06835919, Ketohexokinase inhibitor 1 supplier, Ketohexokinase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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PF-06835919

Ketohexokinase inhibitor 1

Quality Control & Documentation

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