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PF-06747775

Cat. No. M8089

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PF-06747775 Structure

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Quality Control & Documentation
Biological Activity

PF-06747775 is an orally available, potent and selective inhibitor of the epidermal growth factor receptor) mutant form T790M (EGFR T790M inhibitor). PF-06747775 exhibits minimal activity against wild type EGFR.

Chemical Information
Molecular Weight 415.42
Formula C18H22FN9O2
CAS Number 1776112-90-3
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Harun Patel, et al. Recent updates on third generation EGFR inhibitors and emergence of fourth generation EGFR inhibitors to combat C797S resistance

[2] Simon Planken, et al. Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants䲧畸Ỵ畹㧀畷羹皖睑ꓸऒŤऒĀ

[3] Shuhang Wang, et al. Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer

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Keywords: PF-06747775 supplier, inhibitors, activators

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