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PF-06424439 methanesulfonate is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2) with an IC50 of 14 nM.
In vivo, PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-).
| Molecular Weight | 536.05 |
| Formula | C22H26ClN7O.CH3SO3H |
| CAS Number | 1469284-79-4 |
| Solubility (25°C) | Water 60 mg/mL DMSO 200 mg/mL |
| Storage | 4°C, dry, sealed |
| Related DGAT Products |
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| A-922500
A-922500 (DGAT-1 Inhibitor 4a) is a potent and selective DGAT-1 inhibitor with IC50 values of 9 and 22 nM at human and mouse DGAT-1 respectively. |
| AZD7687
AZD7687 is a reversible and selective DGAT1 inhibitor with IC50 value of 80 nM. |
| PF-04620110
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
| AZD 3988
AZD 3988 is a potent and selective DGAT-1 inhibitor. |
| T863
T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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