All AbMole products are for research use only, cannot be used for human consumption.
For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.
PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
| Molecular Weight | 396.36 |
| Formula | C18H19F3N4O3 |
| CAS Number | 1215197-37-7 |
| Solubility (25°C) | DMSO 39.64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Wright, et al. Neuron. The lipid kinase PIP5K1C regulates pain signaling and sensitization.
| Related Glucokinase (GK) Products |
|---|
| LY2608204
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. |
| AM2394
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM. |
| Dorzagliatin
Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a glucokinase (GK) activator, which improves glycaemic control and pancreatic β-cell function for type 2 diabetes. |
| AZD1656
AZD1656 is a potent, selective and orally active glucokinase (GK) activator, with an EC50 of 60 nM. |
| Cadisegliatin (TTP-399)
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
