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PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC50 = 131 nM) but has low potency against the rat Nav1.7 channel (IC50 = 4.2 mM). PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors.
| Molecular Weight | 437.49 |
| Formula | C20H15N5O3S2 |
| CAS Number | 1235397-05-3 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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