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PF-04418948 inhibited prostaglandin E(2)(PGE(2))-induced increase in cAMP in cells expressing EP(2) receptors with a functional K(B) value of 1.8 nM. In human myometrium, PF-04418948 produced a parallel, rightward shift of the butaprost-induced inhibition of the contractions induced by electrical field stimulation with an apparent K(B) of 5.4 nM. In dog bronchiole and mouse trachea, PF-04418948 produced parallel rightward shifts of the PGE(2)-induced relaxation curve with a K(B) of 2.5 nM and an apparent K(B) of 1.3 nM respectively. Reversal of the PGE(2)-induced relaxation in the mouse trachea by PF-04418948 produced an IC(50) value of 2.7 nM.
Acad Radiol. 2026 Jan 19; .
Improvement of Tumor Hypoperfusion and Hypoxia via Low-intensity Ultrasound-stimulated Microbubbles Combined with Alprostadil
PF-04418948 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | 0.5% methylcellulose, 0.2% Tween 80 in saline |
| Dosages | 10 mg/kg |
| Administration | i.p. or oral gavage |
| Molecular Weight | 409.41 |
| Formula | C23H20FNO5 |
| CAS Number | 1078166-57-0 |
| Solubility (25°C) | DMSO: ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Prostaglandin Receptor Products |
|---|
| Ethamsylate
Ethamsylate is a haemostatic compound, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion. |
| Tafluprost
Tafluprost is a fluorinated analog of prostaglandin F2-alpha and a PGF2alpha agonist that may be used in glaucoma-related studies. |
| Terutroban
Terutroban is a selective antagonist of the thromboxane receptor. |
| Prostaglandin E1
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, which induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. |
| Latanoprost
Latanoprost is a prostaglandin F2α analog as well as a prostaglandin-like selective FP receptor agonist with lipophilic and corneal penetrating properties. In addition, Latanoprost also increases ocular fluid outflow, thereby reducing intraocular pressure, and may be used in studies related to glaucoma. |
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