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PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain. PF-03382792 produces moderate increases in cortical Ach in the rat prefrontal cortex. PF-03382792 can be used for the research of Alzheimer's disease.
Acta Pharmacol Sin. 2025 Dec 01; .
Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors.
PF-03382792 purchased from AbMole
| Molecular Weight | 433.52 |
| Formula | C23H32FN3O4 |
| CAS Number | 1400811-63-3 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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