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Peramivir Trihydrate is a trihydrate of the anti-infection agent Peramivir Trihydrate which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. The IC50 for Peramivir Trihydrate is markedly lower than that for either zanamivir or oseltamivir. Peramivir Trihydrate increases survival in preclinical influenza models, including mouse and ferret models of highly pathogenic avian influenza H5N1. One day of treatment with Peramivir Trihydrate is active, and multiple days of treatment rescues most or all mice with H5N1. Similar data have been obtained in ongoing murine experiments with seasonal influenza A (H1N1)/H274Y.
Theranostics. 2022 Jul 7;12(12):5317-5329.
Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
Peramivir Trihydrate purchased from AbMole
| Molecular Weight | 382.45 |
| Formula | C15H28N4O4.3H2O |
| CAS Number | 1041434-82-5 |
| Solubility (25°C) | Water 4 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] No authors listed. Peramivir
[3] No authors listed. Aust Prescr. Peramivir for influenza
[4] Lesley J Scott. Peramivir: A Review in Uncomplicated Influenza
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