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Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it causes panic attacks.
| Molecular Weight | 767.89 |
| Formula | C37H49N7O9S |
| CAS Number | 5534-95-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[1] Diana Radu, et al. Pentagastrin test for anxiety--psychophysiology and personality
[2] A S de Leeuw, et al. Pentagastrin has panic-inducing properties in obsessive compulsive disorder
[3] R M Wexler, et al. Pentagastrin in diffuse oesophageal spasm
| Related Cholecystokinin Receptor Products |
|---|
| Proglumide sodium salt
Proglumide sodium salt is a non-selective, orally active cholecystokinin (CCK) antagonist. |
| Lintitript
Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). |
| Lorglumide sodium salt
Lorglumide (CR-1409) sodium salt is a potent cholecystokinin (CCK) receptor antagonist. |
| Ceruletide
Ceruletide is a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, acts as a cholecystokinin receptor agonist. |
| Gastrin-I (human)
Gastrin-I (human) is the endogenous peptide produced in the stomach, which increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
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