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Pemigatinib (INCB054828) is an orally effective, selective FGFR inhibitor with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Pemigatinib binds to and inhibits FGFR1/2/3, which inhibits proliferation in FGFR1/2/3 overexpressing tumor cells. pemigatinib exhibited antitumor activity in mouse xenograft models of human tumors with altered FGFR1, FGFR2 or FGFR3.
| Molecular Weight | 487.5 |
| Formula | C24H27F2N5O4 |
| CAS Number | 1513857-77-6 |
| Solubility (25°C) | DMSO ≥ 32 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FGFR Products |
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| AZD4547
AZD4547 (Fexagratinib) is a potent, selective and orally active pan-FGFR inhibitor with IC50s of 0.2. 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. |
| BGJ398 (Infigratinib)
BGJ398 (Infigratinib) is a potent and selective FGFR kinase inhibitor with IC50 values of 0.9 nM, 1.4 nM, 1 nM and 60 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. |
| PD173074
PD173074 is a selective FGFR1 and FGFR3 inhibitor with IC50 values of 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively. |
| SSR128129E
SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs. |
| LY2874455
LY2874455 is a novel and potent FGF/FGFR inhibitor. |
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