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Pegcetacoplan is a polyethylene glycolated peptide and an inhibitor of complement protein C3 that inhibits intravascular and extravascular hemolysis.
| Cell Experiment | |
|---|---|
| Cell lines | HMEC-1 cells |
| Preparation method | HMEC-1 cells were activated with 10 µM ADP, then incubated with either pooled NHS or primary aHUS serum (aHUS3–5, diluted 1:2 in HBSS + 0.5% BSA) in the presence or absence of CPV-104 (500 µg/ml), sd-FH (500 µg/ml) or pegcetacoplan (1 mg/ml) for 4 h at 37°C. |
| Concentrations | 1 mg/mL |
| Incubation time | 4 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| CAS Number | 2019171-69-6 |
| Storage | -20°C, protect from light, dry, sealed |
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|---|
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| JPE-1375
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| Compstatin
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| Avacopan
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