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KP372-1 

Cat. No. M28281

All AbMole products are for research use only, cannot be used for human consumption.

KP372-1  Structure

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Quality Control & Documentation
Biological Activity

KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer).

Chemical Information
Molecular Weight 448.36
Formula C20H8N12O2
CAS Number 1374996-60-7
Form Solid
Solubility (25°C) DMSO 17.86 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lingxiang Jiang, et al. Front Oncol. KP372-1-Induced AKT Hyperactivation Blocks DNA Repair to Synergize With PARP Inhibitor Rucaparib via Inhibiting FOXO3a/GADD45α Pathway

[2] M Mandal, et al. Br J Cancer. Retraction Note to: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells

[3] Talysa Viera, et al. Sci Rep. DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition

[4] A Österroos, et al. Biochem Pharmacol. Combination screening in vitro identifies synergistically acting KP372-1 and cytarabine against acute myeloid leukemia

[5] Yuzheng Zhao, et al. Cell Metab. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

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  Catalog
Abmole Inhibitor Catalog




Keywords: KP372-1  supplier, Akt, inhibitors, activators

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