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PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.
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Source | Vascul Pharmacol (2013). Figure 1. PD173955 |
| Method | western blot | |
| Cell Lines | HAECs | |
| Concentrations | 5 μM | |
| Incubation Time | 30 min | |
| Results | PD173955 and PP2 suppressed PLC-induced increase in eNOS phosphorylation and activity. |
| Molecular Weight | 443.35 |
| Formula | C21H16Cl2N4OS |
| CAS Number | 260415-63-2 |
| Solubility (25°C) | DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] George A Kraus, et al. New effective inhibitors of the Abelson kinase
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