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BMS202

Cat. No. M5144

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BMS202 Structure
Synonym:

PD-1/PD-L1 inhibitor 2

Size Price Availability Quantity
1mg USD 40 In stock
5mg USD 98 In stock
10mg USD 150 In stock
25mg USD 305 In stock
50mg USD 500 In stock
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Quality Control & Documentation
Biological Activity

Bms-202 is an effective non-peptide PD-1/PD-L complex inhibitor with IC50 of 18 nM and KD of 8 μM. Bms-202 directly binds to PD-L1 and blocks the human PD-1/PD-L interaction. Bms-202 has antitumor activity.

Product Citations
Chemical Information
Molecular Weight 419.52
Formula C25H29N3O3
CAS Number 1675203-84-5
Solubility (25°C) DMSO: ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rui Zhang, et al. Small. Immune Checkpoint Blockade Mediated by a Small-Molecule Nanoinhibitor Targeting the PD-1/PD-L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer

[2] Zak KM, et al. Structure. Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.

[3] Zak KM, et al. Oncotarget. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).

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Keywords: BMS202, PD-1/PD-L1 inhibitor 2 supplier, PD-1/PD-L1, inhibitors, activators

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