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PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases.
| Molecular Weight | 1852.17 |
| Formula | C89H126N24O18S |
| CAS Number | 1629654-95-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Tian Tian, et al. Front Oncol. Targeting Tim-3 in Cancer With Resistance to PD-1/PD-L1 Blockade
[5] Yanyan Han, et al. Am J Cancer Res. PD-1/PD-L1 pathway: current researches in cancer
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