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PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases.
| Molecular Weight | 1966.19 |
| Formula | C91H127F3N24O20S |
| Form | Solid |
| Solubility (25°C) | Water 50 mg/mL (ultrasonic) |
| Storage | Store at ≤ -20°C, protect from light, dry, sealed |
[4] Yanyan Han, et al. Am J Cancer Res. PD-1/PD-L1 pathway: current researches in cancer
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