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PAT-1251

Cat. No. M10956

All AbMole products are for research use only, cannot be used for human consumption.

PAT-1251 Structure

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Quality Control & Documentation
Biological Activity

PAT-1251 is a potent, selective, orally lysanyl oxidase-like protein 2 (LOXL2) inhibitor of hLOXL2 and hLOXL3 IC50 The values were 0.71 and 1.17 μM, respectively, and the inhibition of LOXL2 in mice, rats, and dogs was strong.IC50 Values are 0.10, 0.12, and 0.16 μM, respectively; PAT-1251 can be used for studies of a variety of fibrous diseases.

Chemical Information
Molecular Weight 399.34
Formula C18H17F4N3O3
CAS Number 2007885-39-2
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Martin W Rowbottom, et al. J Med Chem. Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

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  Catalog
Abmole Inhibitor Catalog




Keywords: PAT-1251 supplier, Monoamine Oxidase, inhibitors, activators

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