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Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. Pasireotide (SOM 230) exhibits unique high-affinity binding to human somatostatin receptors sst1/2/3/4/5 with pKi of 8.2/9.0/9.1/<7.0/9.9 respectively. In cultures of human fetal pituitary cells, SOM230 inhibited GH secretion by 42 +/- 9% (P = 0.002) but had no effect on TSH release. SOM230 inhibited GH release from GH-secreting adenoma cultures by 34 +/- 8% (P = 0.002), PRL by 35 +/- 4% from PRL-secreting adenomas (P = 0.01), and alpha-subunit secretion from nonfunctioning pituitary adenomas by 46 +/- 18% (P = 0.34).
| Molecular Weight | 1047.21 |
| Formula | C58H66N10O9 |
| CAS Number | 396091-73-9 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Somatostatin Receptor Products |
|---|
| Octreotide Acetate
Octreotide acetate(SMS 201995 acetate) is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin. |
| Cyclosomatostatin acetate
Cyclosomatostatin acetate is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin acetate can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells. |
| FK962
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. |
| Lanreotide
Lanreotide is a somatostatin analogue, acts as an inhibitor of growth hormone (GH). |
| Somatostatin
Somatostatin is a tetradecapeptide which can suppress the growth hormone (GH) secretion, and regulate the endocrine system to control the pituitary hormone secretion in human CNS. |
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